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February 12, 2023February 17, 2023

Do XY females have testes?

Do XY females have testes?

Women with CAIS are born with an XY chromosome pair. Because of the Y chromosome, the women have testes that remain hidden within their groins but they lack neural receptors for androgens so they cannot respond to the androgens that their testes produce.

Do XY females have ovaries?

The karyotype reveals XY chromosomes and the imaging demonstrates the presence of a uterus but no ovaries (the streak gonads are not usually seen by most imaging).

Are XY females sterile?

Such gonads are typically surgically removed (as they have a significant risk of developing cancer). The typical medical treatment is hormone replacement therapy. The syndrome was named after Gerald Swyer, an endocrinologist based in London….

XY gonadal dysgenesis
Specialty Medical genetics

Can you be female with XY chromosomes?

The X and Y chromosomes are called “sex chromosomes” because they contribute to how a person’s sex develops. Most males have XY chromosomes and most women have XX chromosomes. But there are girls and women who have XY chromosomes. This can happen, for example, when a girl has androgen insensitivity syndrome.

What is XY phenotype?

Background. The 46,XY female is characterised by a male karyotype and female phenotype arising due to any interruption in the sexual development pathways in utero. The cause is usually genetic and various genes are implicated.

Are XX and XY chromosomes only?

Many people of course are arguing there are only just two genders (i.e. sexes) male and female. But in doing research, there seem to be more combinations at least at the DNA level. Instead of just XX and XY, there can be XXX, XXY, and X and many others besides.

Why do some people have XY female genitalia?

  • Malformation syndromes such as Smith Lemli –Opitz and Campomelic dysplasia also have 46 XY karyotype with female or ambiguous genitalia. These occur due to mutations in the autosomal genes DHCR7 (which codes for 7-dehydrocholesterol reductase) or it could be due to deletions in the autosomal gene SOX-9

Can a karyotype show a gonad with no ovaries?

  • The karyotype reveals XY chromosomes and the imaging demonstrates the presence of a uterus but no ovaries (the streak gonads are not usually seen by most imaging).

Why are people with Swyer syndrome called XY female?

  • Campomelic dysplasia causes skeletal abnormalities. A person with Swyer syndrome may also be called an XY female, because people with Swyer syndrome are usually raised as girls and have a female gender identity. This isn’t always the case, however, as with all humans, variations occur in gender identity.

What happens when the XY gonads do not differentiate into testes?

  • When such a gene is defective, the indifferent gonads fail to differentiate into testes in an XY fetus. Without testes, no testosterone or antimüllerian hormone (AMH) is produced. Without testosterone, the wolffian ducts fail to develop, so no internal male organs are formed.
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